The Yeast monitor 720 range has incorporated the latest developments in radio-frequency impedance that allows a higher specification instrument to be manufactured at a lower cost.

The Yeast Monitor Model 720 has an integral multiplexer, allowing the unit to be expanded up to 4 channels and it is completely contained within a stainless steel IP65 enclosure.

The Model 720 has the flexible option of monitoring from the same instrument both yeast slurries and the relatively low cell concentrations found in propagators or krausening operations.

Communication options include separate 4-20mA outputs for live cell concentration and conductivity and options for Profibus and other fieldbus communications to the PLC.

Calibration is quick and simple with a new auto-calibration option.

Yeast Monitor 720 Data Sheet

The Yeast Monitor Model 710is ideal for a dedicated yeast pitching or cropping application requiring only one probe.

Over 50% of the world’s major breweries now use the Yeast Monitor. Customers include AB Inbev, SAB Miller, Heineken, Coors, Diageo, Carlsberg, Suntory and many independant breweries.

The Yeast Monitor 710 range has incorporated the latest developments in radio-frequency impedance that allows a higher specification instrument to be manufactured at a lower cost.

The Yeast Monitor Model 710 is completely contained within a stainless steel IP65 enclosure and is capable of monitoring a wide range of cell concentrations from yeast slurries to the relatively low cell concentrations found in propagators or krausening operations.

Communication options include separate 4-20mA outputs for live cell concentration and conductivity and options for Profibus and other fieldbus communications to the PLC.

Yeast Monitor 710 Data Sheet

At Drinktec 2009, Aber presented the next generation of "Compact" Yeast Monitors designed for breweries that require competitively priced, user-friendly instruments for pitching and cropping applications. With the new range Aber has condensed its advanced radio-frequency impedance technology into a compact IP65 housing that fits easily on to standard instrument housings such as the Tuchenhagen Varivent. For the most cost effective solution, the instrument can communicate directly to the PLC via Profibus or a 4-20mA current loop and an optional transmitter will be available if required.

In order to simplify calibration and start up the "Compact" series will be suitable for breweries that use up to 2 yeast strains and it will have a tighter restriction of yeast conductivity compared with previous models. The "Compact" Yeast Monitors are designed to be used in real time with yeast slurries in the range of 5-70% viable spun solids and the system is maintenance free.

The Biomass Monitor Model 200 is a response to the demand in the industry for a lower cost unit that is simple to use, flexible with communications and that will also meet the strict validation requirements of the manufacturing process including GAMP 4 compliance. The unit is designed to be dedicated to single bioreactor (ideal for cGMP) and overcomes the inconvenience of running multiple cables to bioreactors. These new features combine to make the BM 200 the most customer orientated device for live cell mass monitoring.

Key user benefits

• Affordable The Model 200 is lowest cost option for monitoring LIVE biomass on-line
• Simple to use-plug and play There are just 3 modes of operation to cover cell culture and yeast or bacterial fermentations
• Validatable The Model 200 can be provided with full IQ/OQ documentation and is designed to GAMP4 requirements with password protection
• Small Footprint At just 27cm in width, the instrument fits neatly onto an instrument stack or into a panel
• Dedicated instrument for each bioreactor The reduced complexity of a single channel system is the choice for cGMP
• Intelligent probes The probes are immediately recognized when connected to the transmitter-eliminates difficult configuration procedures

Biomass Monitor Model 200 Data Sheet

The Aber Futura is the complete instrument; it has all the biomass monitoring processing power contained within a compact housing. Each connected probe has unique calibration data stored in a processor within the probe body allowing the Futura to automatically detect and identify the connected probe. Information on the probe life cycle can be provided by an intelligent sensor management software system.

Like all Aber products, the Futura can be provided with full IOQ documentation making it the ideal choice for cGMP cell culture. Changes to the Futura configuration are tracked in it's integral 2 gigabyte memory so a full audit trail is always available.

The Futura will be offered in three configurations to meet your needs. In each case, no additional transmitter or complex multiplexer is required and the customer can use their own PC or fermenter control system(including via OPC) to configure the simple options for measuring different cell types. There is no restriction on the number of instruments that can be controlled from a PC or control system. The Standard Futura can be provided with a low cost PLC based colour touch screen if a local display is required.

Aber Instruments is launching in 2009 the Futura, a new generation of compact, lightweight biomass monitoring instrumentation in that can be used on conventional and disposable bioreactors.

Futura Range Data Sheet

The Biomass Monitor Model 200 was produced in response to the demand in the industry for a lower cost unit that is simple to use, flexible with communications and that will also meet the strict validation requirements of the manufacturing process including GAMP 4 compliance.

The unit is designed to be dedicated to single bioreactor (ideal for cGMP) and overcomes the inconvenience of running multiple cables to bioreactors. These new features combine to make the BM 200 the most customer orientated device for live cell mass monitoring.

Key user benefits

• Affordable The Model 200 is lowest cost option for monitoring LIVE biomass on-line
• Simple to use There are just 3 modes of operation to cover cell culture and yeast or bacterial fermentations
• Validatable The Model 200 can be provided with full IQ/OQ documentation and is designed to GAMP4 requirements with password protection
• Small Footprint At just 27cm in width, the instrument fits neatly onto an instrument stack or into a panel
• Dedicated to one bioreactor The reduced complexity of a single channel system is the choice for cGMP

Biomass Monitor Model 200 Data Sheet

The Biomass Monitor Model 220 has an integral Multiplexer allowing up to 4 fermenters to be monitored. Advanced facilities are available with the Model 220 such as frequency scanning, polarisation correction and a multiple frequency system for aerated fermenters. The unique frequency scanning function on the Model 220 can allows changes in cell viability, cell size and metabolic activity of the cells to monitored

Areas of use:

• The Biomass Monitor 220 can be used with all conventional bioreactors for the measurement of viable bacteria, yeast, animal, plant and other cellular biomass.
• Cells can be measured whilst in free suspension or immobilised on inert carriers such as glass beads and microcarriers.
• The system is ideal for research/pilot plants but full IOQ documentation can be provided for cGMP.

Key user benefits

• Multiple frequency scanning Addition of FREE Aberscan software can provide additional information on size distribution/viability and metabolic state of the organism
• Measuring frequency easily change enabling you to monitor a range of different cell types
• Expandable Start with a one channle unit and expand to up to 4 fermentors
• Transportable and easily stacks on fermenter controller The BM220 can esaily be moved to different fermenters throughout the lab and each channel can be set up for different organisms
• Intelligent probes The probes are immediately recognized when connected to the transmitter-eliminates difficult configuration procedures
• Validatable The BM220 can be validated for use in cGMP.

Biomass Monitor Model 220 Data Sheet

Biomass Monitor 230has become the first choice system for many of the major biopharma companies operating cGMP bioreactors

The model Biomass Monitor 230 has been designed specificallyfor measurements of live cell concentration and media conductivity in a cGMP. To ensure simplicity of use there are minimum set-up options. Housed in an IP65 rated enclosure and supplied with FDA approved Stainless steel /Peek probe, it is an ideal option for specifying in a cGMP facility. Full IOQ documentation can be provided with this instrument. The instrument can be set up to measure in live cells/ml, capacitance, g/L or a user defined option.

Areas of Use

• Biomass Monitor 230 is designed specifically for live cell mass monitoring in cGMP or industrial environments.
• It can be used with most conventional bioreactors for the measurement of viable bacteria, yeast, animal, plant and other cellular biomass.
• Cells can be measured whilst in free suspension or immobilised on inert carriers such as glass beads and microcarriers.
• Communication options include individual 4-20mA current loop outputs for each channel, RS232 and Profibus.

Key user benefits

• Validatable The BM230 is the first choice instrument for cGMP cell culture. Over 50 systems are being operating under cGMP.
• Multiplexing capability Integral multiplexer for up 4 probes allowing the system to be expanded in the future.
• Simple to use and configure The BM230 is microprocessor based and has minimal settings and screens. It can still be optimised for specific applications and simple to configure.
• Intelligent probes The probes are immediately recognized when connected to the transmitter-eliminates difficult configuration procedures
• Built within enclosure Essential for a wetted or contained production environment. Protects instrument to IP 65

Biomass Monitor Model 230 Data Sheet

Aber is pleased to introduce two new additions to our product range. The Aber Probe Testers:

• Check the integrity of any type of Aber Probe
• Quick and simple to use
• Two versions availabe, 1 for the production environment (pass/fail readout) and 1 for in depth tracking of the tests (LCD display)

The Aber Probe Tester has been specially designed to carry out checks on the integrity of any type of on-line probe used with all Aber Biomass Monitor systems. This includes probes from the older generation of Biomass Monitors (eg Models 214 and 520).

The tester will automatically run through a sequence of tests for internal corrosion and leakage between the electrodes. The complete test procedure checks the health of a probe and its ability to perform correctly.

There are two versions of this instrument one intended for a production environment providing a simple Pass or Fail result. The other has an LCD display that allows the user to track the progress of testing of a probe.

Aber is pleased to announce the release of its new AberScan software. The software simplifies the frequency scanning measurements first proposed by Aber in the 1990's.

• Enables detection of key additional parameters, for identifying major transition points in cell culture and fermentation processes
• Simple to use software

The AberScan software package can improve the accuracy of the biomass measurement and provides a number of additional parameters that can be linked to critical events during fermentation and cell culture.

By applying frequency scanning on capacitance and conductance values at 25 different frequencies between 0.1 MHz and 20 MHz. the software computes additional process parameters including the dielectric increment, cole-cole alpha (a) and critical or characteristic frequency (fc).

A number of papers have already shown that frequency scanning can be a powerful tool for identifying major transition points in cell culture and fermentation and changes in the cell membrane capacitance. In one study, the changes in cell membrane capacitance appear to be linked with the onset of apoptosis when the cells shrink and the cell membrane undergoes folding.

Aber Log Gold is data logging software package that can be used with the Models 210,220, 230 and 920.

It has a range of features including logging of capacitance and conductivity over user defined logging intervals, multiple channel logging (up to 4 channels), data manipulation and exporting of data in .csv format for use with other graphical packages including Excel.

Designed to run with Windows XP or Vista.