Real time means real savings. Cells with intact plasma membranes in a fermenter can be considered to act as tiny capacitors under the influence of an electric field. The non-conducting nature of the plasma membrane allows a build up of charge.
The resulting capacitance can be measured; It is dependent upon the cell type and is directly proportional to the membrane bound volume of these viable cells.
The technology is ideal for viable yeast, bacteria, animal, plant and other cellular biomass.
A unique patented probe that is steam sterilisable in situ incorporates 4 electrodes is used to apply a radio frequency to the biomass. Electronic processing of the resulting signals produces an output which is an accurate measurement of the concentration of viable cells. The probe is constructed of wetted materials conform to FDA making the system ideal for scale build up in GMP facilities.
The system is responsive to viable cells and is insensitive to cells with leaky membranes, gas bubbles and cells debris. Unlike conventional optical measurement techniques, the Aber method is not prone of fouling. It can also monitor very high biomass concentrations and operate in a wide range of complex culture media.

Biomass Monitor 210 Data Sheet...Click Here

• A new improved 2-frequency system that will allow improvements in sensitivity and accuracy under highly aerated conditions
• Continuous on-line measurement of gas holds up and conductivity for additional process information
• Integral multiplexer reducing the cost per channel
• 19mm & 25mm diameter probes designed for GMP facilities

Real time means real savings. Cells with intact plasma membranes in a fermenter can be considered to act as tiny capacitors under the influence of an electric field. The non-conducting nature of the plasma membrane allows a build up of charge.
The resulting capacitance can be measured; It is dependent upon the cell type and is directly proportional to the membrane bound volume of these viable cells.
The technology is ideal for viable yeast, bacteria, animal, plant and other cellular biomass.
A unique patented probe that is steam sterilisable in situ incorporates 4 electrodes is used to apply a radio frequency to the biomass. Electronic processing of the resulting signals produces an output which is an accurate measurement of the concentration of viable cells. The probe is constructed of wetted materials conform to FDA making the system ideal for scale build up in GMP facilities.
The system is responsive to viable cells and is insensitive to cells with leaky membranes, gas bubbles and cells debris. Unlike conventional optical measurement techniques, the Aber method is not prone of fouling. It can also monitor very high biomass concentrations and operate in a wide range of complex culture media.

Biomass Monitor 220 Data Sheet...Click Here

• Measures viable cell concentration in real time from 0 to 99.9% viable solids or 10⁶ cells/ml to 999 x 10⁹ cells/ml
• Insensitive to trub and gas bubbles
• Selectable unit of measurement, Viable % spun solids or cells/ml
• User adjustable high and low concentration alarms
• RS232C Serial port as standard, Other options available
• Yeast strain selector to allow calibration for 10 different yeast strains
• Clear LCD screen to ease set up and calibration with on screen menus
• Probe resistant to normal CIP processes and steam sterlisation
• Optional multiplexer enables one instrument to monitor up to 8 probes

Yeast Monitor 320 Data Sheet...Click Here

• Concentration range:
  Low Range: 10-200 x 10⁶ viable cells/ml
  High Range: 2x10⁸ to 10¹⁰ viable cells/ml or 5-70% viable spun solids
• Accuracy:
  High Concentration: typical C.V <3%
  Low Concentration: typical C.V. 2 to 12% depending on cell size and concentration
• Drift: Typically less than 0.5% spun solids over 6 months in high concentration mode
• Normal conductivity operating range:
  Low Mode: 0.65 to 2.5 mS/cm
  High Mode: 0.65 to 7.5 mS/cm
• Conductivity measurement range: 0 to 26 mS/cm
• Measuring Frequency: 0.31 MHz
• Strain Selection: 10 strain positions, selected by switch or remotely.
• Alarms: Relay contact (Normally Open) indicate conductivity or concentration out of range and probe or instrument fault
• Power: 110 - 230VAC
• Enclosure: 4U, 19" rack mount

Yeast Monitor 330LC Data Sheet...Click Here

The Yeast Switch YS700 for Viable Yeast Cropping Control

• Developed specifically for the yeast recovery process in breweries
• Uses the proven Aber capacitance method of measurement
• Detects changes in the level of viable yeast concentration
• Instructs the PLC when the concentration reaches a pre-set threshold
• Simple, low cost installation and set-up

Yeast Switch YS700 Data Sheet...Click Here

Measures the concentration of live yeast biomass in brewing fermentation applications

• Range: 0 to 400 million cells/ml
  Conductivity: 0.65 to 2.5mS/cm
• Accuracy: 2 to 12% depending on cell size, conductivity range and zeroing procedure
• Communications: RS232, 4-20mA loops (8) and PLC Logic I/O
• Power: 110 - 230 VAC
• Enclosure: IP65 Waterproof Stainless Steel, wall mounting
  4 head amplifier connectors and 2 cable glands/blanks
  Optional Lock
• Head Amplifier: IP65, 2metre cable (Optional up to 100m)

Yeast Monitor 730 Data Sheet...Click Here

For off-line concentration measurement of viable yeast

• Measurement Units - User Selectable
  viable cells/ml, viable % spun solids or viable g/l
• Yeast Strains: User selectable for up to 10 strains
• Range:
  Model 800:
  2 x 10⁸ to 10¹⁰ viable cells/ml
  5 - 70% viable spun solids
  10 - 140 g/l viable dry weight
  Model: 810LC
  Low Range:
  10 - 200 x 10⁶ viable cells/ml
  High Range:
  2 x 10⁸ to 10¹⁰ viable cells/ml
  5 - 70% viable spun solids
  10 - 140 g/l viable dry weight
• Resolution:
  Low Range: Typically 1 x 10⁶ cells/ml depends on size & concentration
  High Range: Typically 0.1% spun solids
• Sample size: 10ml
• Power: 110 - 230 VAC

Lab yeast Analyser 800 & 810LC Data Sheet...Click Here

Live Cell Analyser 920 is a unique dual-purpose instrument for either off-line or on-line measurement of live biomass. It uses the acclaimed state of the art capacitance technology from Aber Instruments that has become the standard measurement for biomass in companies throughout the world. You have the option of taking a sample from a bioreactor or flask and then transferring to the Model 920 for a live biomass measurement. Alternatively, the Live Cell Analyser an can be used as a on-line instrument for bioprocess monitoring and control by connecting to an Aber biomass probe within your bioreactor.

Used as a laboratory instrument, the 920 allows the viable biomass concentrations to be measured within seconds with high precision and repeatability. With yeasts or animal cell it can free up time by eliminating time consuming dilution, manual counting under the microscope and the addition of dyes. Cells attached to micro carriers can measured without any pretreatment to provide a true live cell count. With applications such as filamentous bacteria (e.g. streptomyces) and fungi (e.g. penicillium) the Aber technology is the only method available for live biomass estimation within seconds.

KEY BENEFITS OF THE Live Cell Analyser 920

• DUAL FUNCTION
  The 920 is the only instrument that can function as either on-line or be used as a multi-purpose biomass instrument for bioreactor samples
• VERSATILE
  Suitable for all types of cells so one instrument can cover multiple applications
• IDEAL FOR EVALUATING TECHNOLOGY
  The Aber Biomass Monitor is widely used in production including GMP applications. The Model 920 is the perfect tool for assessing Aber technology on your cell line and process.
• NO EXPENSIVE REAGENTS and EASY TO USE
  Live cell measurement is provided without the errors of dilution and without additional reagents or cassettes.
• MEASURES TRUE LIVE BIOVOLUME
  The viable biovolume measured with the 920 is the "biocatalyst" in a bioreactor and it will provide a unique indication of the physiological state of the process.
• PROCESS CONTROL
  The Aber 920 can be used to control nutrient feeding or perfusion rates when used in the on-line mode.